The Computational and Information Sciences and Technology Office (CISTO), Code 606, at NASA’s Goddard Space Flight Center (GSFC) was established in January 2005 and is a Directorate-level organization which serves as the focal point for Information Technology (IT) and computational services to support the research programs of the Science and Exploration Directorate (SED). CISTO manages and operates the NASA Center for Computational Sciences.

The civil servants and contractors of CISTO are committed to supporting NASA's vision for the future. CISTO supports the Agency by providing the science community with access to state-of-the-art high-performance computing and networking, mass storage and information systems technologies, and dedicated computational science expertise. These resources and expertise enable NASA-supported scientists to increase their understanding of Earth, the solar system, and the universe through computational modeling and processing of spaceborne observations. CISTO supports the Agency's empowering goals through the individual efforts of CISTO staff and a number of educational and outreach programs.

CISTO is composed of the Directorate-level Office and three functional areas: Networks and IT Security, High Performance Computing, and Information Science and Technology Research.

CISTO is also the Directorate’s interface with the Goddard Chief Information Officer (CIO) and Center IT organizations (Code 700) regarding information technologies such as IT security policy, implementation and services; Enterprise Architecture development and compliance; strategic IT investment planning and management; and appropriate implementation of NASA and GSFC IT policies and initiatives to ensure Directorate compliance. CISTO also develops strategies to optimize cost-effectiveness in the utilization of information technologies in support of the Directorate’s mission.